UNIT 3-Module 7-Ch14,15.pdf - UNIT 3-Module 7-Ch14,15 Vocab...

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UNIT 3-Module 7-Ch14,15 Vocab Ch14: The Innate Immune Response 1. activated macrophage→ stimulated by cytokines to enlarge and become metabolically active with increased capability to kill and degrad intracellular organisms and materials 2. acute inflammation→ short-term inflammatory response marked by a prevalence of neutrophils 3. adhesion molecule→ molecule on the surface of a cell that that allows that cell to adhere to other cells 4. alternative pathway→ pathway of complement system that is triggered when C3b binds to foreign cell surfaces 5. apoptosis→ programmed cell death that does not trigger an inflammatory response 6. basophil→ about 1%) leukocytes with large dark-staining granules that contain histamine and other inflammatory mediators. Involved in allergic reactions and therefore have receptors on surface that bind IgE. 7. chemokines→ type of cytokine important in chemotaxis of cells of the immune system. Some cells have receptors for this allowing them to sense the location in which they are needed. 8. chronic inflammation→ long-term inflammatory response in which macrophages and giant cells accumulate causing granulomas to form. 9. classical pathway→ pathway of complement system that is activated when antibodies bind to antigen which then interact with the complement system 10. colony stimulating factors (CSFs) → cytokines that stimulate growth and differentiation of leukocytes 11. complement system→ series of serum (circulating in blood and bathing tissues) proteins involved with innate immunity. It is activated by 3 different pathways that lead to the formation of C3 convertase which then splits C3. 12. cytokines→ small regulatory proteins that cells produce to affect behavior of other cells. Act at low concentration and their effects can be local, regional and/or systemic. 13. cytokine receptor→ type of surface receptor that binds cytokines thus inducing a change in the cell (i.e growth, differentiation, movement, cell death) 1
UNIT 3-Module 7-Ch14,15 Vocab 14. Danger-associated molecular patterns (DAMPs) → molecules that characterize damaged host cell damage or tissues 15. defensins→ short antimicrobial peptides produced by neutrophils and epithelial cells. They form pores in microbial membranes. 16. Dendritic cell→ leukocytes that act as antigen-presenting cells who usually develop from monocytes. They collect antigen from tissues and bring it to lymphocytes in secondary lymphoid organs. Also play an essential role in the activation of naive T cells . 17. eosinophil→ 2-4%) leukocyte with red staining granules that contain antimicrobial substances and histaminase (enz that breaks down histamine). Important in fighting parasitic infections and allergic reactions. 18. erythrocytes→ red blood cells (RBCs) which carry O 2 in the blood 19. fever→ important host defense mechanism and a strong indicator of infectious disease, especially bacterial.

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