100%(13)13 out of 13 people found this document helpful
This preview shows page 1 - 2 out of 3 pages.
Nurs 6521 WK3 DiscussFactor Affecting Pharmacokinetics and PharmacodynamicsGender can play a role in drug circulation, such as with cardiovascular drug therapy. Gender difference in blood distribution has an impact on pharmacokinetics (Ueno and Sato, 2012). Blood circulation impact clearance rates. Females display reduced liver blood flow rate in which,despite higher Cytochrome P450 3A4 amounts and activity, may result in lower drug clearance. CYP3A4 is the most common and versatile member of the cytochrome P450 family of oxidizing enzymes found in the liver and in the intestine which is involved in drug metabolism.is an important enzyme in the body. It oxidizes small foreign organic molecules such as toxins or drugs, so that they can be removed from the body. Pharmacokinetics and pharmacodynamics must be considered in cardiovascular drug therapy in women.Scenario ThreePatient CB has a history of strokes. The patient has been diagnosed with type 2 diabetes, hypertension, and hyperlipidemia. Drugs currently prescribed include the following:Glipizide 10 mg po dailyHCTZ 25 mg dailyAtenolol 25 mg po dailyHydralazine 25 mg qidSimvastatin 80 mg dailyVerapamil 180 mg CD dailyGender can influence how the body handles a drug as well as what the drug does to the body.