Nurs 6521 WK3 Discuss.docx - Nurs 6521 WK3 Discuss Factor Affecting Pharmacokinetics and Pharmacodynamics Gender can play a role in drug circulation

Nurs 6521 WK3 Discuss.docx - Nurs 6521 WK3 Discuss Factor...

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Nurs 6521 WK3 Discuss Factor Affecting Pharmacokinetics and Pharmacodynamics Gender can play a role in drug circulation, such as with cardiovascular drug therapy. Gender difference in blood distribution has an impact on pharmacokinetics (Ueno and Sato, 2012). Blood circulation impact clearance rates. Females display reduced liver blood flow rate in which, despite higher Cytochrome P450 3A4 amounts and activity, may result in lower drug clearance. CYP3A4 is the most common and versatile member of the cytochrome P450 family of oxidizing enzymes found in the liver and in the intestine which is involved in drug metabolism.is an important enzyme in the body. It oxidizes small foreign organic molecules such as toxins or drugs, so that they can be removed from the body. Pharmacokinetics and pharmacodynamics must be considered in cardiovascular drug therapy in women. Scenario Three Patient CB has a history of strokes. The patient has been diagnosed with type 2 diabetes, hypertension, and hyperlipidemia. Drugs currently prescribed include the following: Glipizide 10 mg po daily HCTZ 25 mg daily Atenolol 25 mg po daily Hydralazine 25 mg qid Simvastatin 80 mg daily Verapamil 180 mg CD daily Gender can influence how the body handles a drug as well as what the drug does to the body.
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