Nurs 6521 WK3 Discuss
Factor Affecting Pharmacokinetics and Pharmacodynamics
Gender can play a role in drug circulation, such as with cardiovascular drug therapy. Gender
difference in blood distribution has an impact on pharmacokinetics (Ueno and Sato, 2012).
Blood circulation impact clearance rates. Females display reduced liver blood flow rate in which,
despite higher Cytochrome P450 3A4 amounts and activity, may result in lower drug clearance.
CYP3A4 is the most common and versatile member of the cytochrome P450 family of oxidizing
enzymes found in the liver and in the intestine which is involved in drug metabolism.is an
important enzyme in the body. It oxidizes small foreign organic molecules such as toxins or
drugs, so that they can be removed from the body. Pharmacokinetics and pharmacodynamics
must be considered in cardiovascular drug therapy in women.
Scenario Three
Patient CB has a history of strokes. The patient has been diagnosed with type 2 diabetes,
hypertension, and hyperlipidemia. Drugs currently prescribed include the following:
Glipizide 10 mg po daily
HCTZ 25 mg daily
Atenolol 25 mg po daily
Hydralazine 25 mg qid
Simvastatin 80 mg daily
Verapamil 180 mg CD daily
Gender can influence how the body handles a drug as well as what the drug does to the body.
