CLAISEN CONDENSATION - the tetrahedral intermediate The...

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CLAISEN CONDENSATION The first step involves adding a strong base to an ester to generate an enolate at the a carbon (note that the enolate has an additional resonance structure). The enolate can then add to another ester molecule by attacking the carbonyl to make
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Unformatted text preview: the tetrahedral intermediate. The carbonyl reforms with loss of the alcoxy group to make the b-keto ester. Example of a Claisen condensation: This is an example of an intramolecular Claisen reaction, called a Dieckmann condensation....
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