E2 REACTION MECHANISM

E2 REACTION MECHANISM - called a concerted step Example of...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
E2 REACTION MECHANISM: SECOND DEGREE ELIMINATION - (transition step) - 3° > 2° > 1° - RDS = bimolecular - strong base (Na + OCH2CH3 - , HOCH2CH3) - likes heat - antiperplanar! - concerted step B : = base X = leaving group (usually halide or tosylate) Base abstracts an H neighboring the LG, forcing the electrons down to make a double bond, and, in so doing, forcing off the leaving group. When numerous things happen simultaneously in a mechanism, such as the E2 reaction, it is
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: called a concerted step . Example of an E2 reaction: Base Strength: A strong base is required since the base is involved in the rate-determining step. Leaving groups: A good leaving group is required, such as a halide or a tosylate, since it is involved in the rate-determining step. Stereochemistry requirements: Must occur with antiperiplanar stereochemistry ....
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online