WILLIAMSON ETHER SYNTHESIS

WILLIAMSON ETHER SYNTHESIS - all flame sources away during...

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WILLIAMSON ETHER SYNTHESIS Overview: The Williamson ether synthesis is a reaction that converts alcohols (R-OH) into ethers (R-O-R). The first step in this reaction is forming the conjugate base of the alcohol (called an alcoxide) by reacting the alcohol with sodium metal. This reaction forms hydrogen gas (H 2 ) as a biproduct, so if you perform this reaction take caution to keep
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Unformatted text preview: all flame sources away during sodium addition. The alcoxide can then be added to a suitable alkyl halide (typically a primary halide) to form the ether via an S N 2 mechanism . Example: An example of the Williamson ether synthesis to make diethyl ether....
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