NUCLEOPHILIC ADDITION TO CARBONYL GROUPS

NUCLEOPHILIC - Variety of nucleophiles-Grignard Reagents-Alcohols-Amines-Alkyl Lithium Reagents-Acetylide Ions Example of nucleophilic addition to

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NUCLEOPHILIC ADDITION TO CARBONYL GROUPS First step is the attack of the nucleophile on the partially positive carbon to make the tetrahedral intermediate with the full negatively charged oxygen . The oxygen then becomes protonated to yield the alcohol.
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Unformatted text preview: Variety of nucleophiles:-Grignard Reagents -Alcohols -Amines -Alkyl Lithium Reagents -Acetylide Ions Example of nucleophilic addition to carbonyl groups: In this case, acetylide anion is acting as the nucleophile....
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This note was uploaded on 03/21/2008 for the course CHEM 261 taught by Professor Austell during the Spring '08 term at UNC.

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