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Chapter 6 Textbook .docx

Chapter 6 Textbook .docx - NEUR 2202 Chapter 6 Synapse...

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NEUR 2202 Chapter 6 Synapse Formation and Maturation 6.2 We can divide synapse structure and development into three parts Synapse can be divided into three components: - Presynaptic terminal which contains neurotransmitter filled synaptic versicels and the machinery to release them (the active zone) - Postsynaptic region which includes postsynaptic densities - Synaptic cleft which is filled with extracellular matrix Maturation of this synapse has three stages 1. Initial contact between the presynaptic terminal and the target cell: mediated by cadherins 2. Assembly of synaptic machinery: in order to release vesicles from presyn and respond to signals in postsyn region 3. Stabilization of the synapse: becomes more elaborate and results in rapid and crisp communication (more effective) 6.3 A synapse begins with adhesion Same adhesive molecules that play a role in axon guidance, bringing the two cells into contact in the first place, also keep them together long enough for other processes to being - Include neural cell adhesion molecule and ephrins - Cadherins and protocadherins stick together in homophilic fashion o Provides a way for axons to display some discrimination, preferring to bind to
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