diabetic drugs-2.docx - Drug Class Beta cell stimulators...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Drug Class Drug MOA Comments Beta cell stimulators Sulfonylurea-like drugs 2 nd gen – Glyburide Non-sulfonylurea-like drugs Meglitinides Repaglinide Nateglinide Stimulate insulin secretion by inhibiting ATP-sensitive K+ channels, prevents repolarization of beta cell insulin flows out HYPOGLYCEMIA! can’t be used in Type 1 Diabetics N, V, Rash, weight gain Hepatotoxicity Teratogenicity (except Glyburide) Meglitinides interact with lipid lower and anti-fungals at P450 Insulin resistance Biguanides Metformin Unk ↓ glucose production ↑ glycogen synthesis ↑ glucose utilization Inhibits lipolysis no gluconeogenesis No Hypoglycemia, No type 1 LACTIC ACIDOSIS in pts with renal impairment or hepatic dysfunction No weight gain HOLD for pts getting contrast N, V, Rash, Metallic taste Glitozones Insulin sensitizers Rosiglitazone Pioglitazone Increases insulin sensitivity decreases insulin resistance by interacting with PPAR transcription factor
Image of page 1
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern