Module 5 – Assignment.pdf

Module 5 – Assignment.pdf - EN 585.629 Cell and Tissue...

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Unformatted text preview: EN 585.629 Cell and Tissue Engineering Module 05: Morphogenesis Assignment Total Point Value = 30 Due by midnight on Day 7 of Module 5 This should be submitted to Blackboard as a pdf. 1. 2. 3. 4. Exercise 3.1 From Tissue Engineering, Saltzman Explain why fingerprints can be used to tell identical twins apart. Describe how semaphorins and slits function similarly in directed migration. Gradient caculations. a. Gradients of soluble morphogen are used to direct both cell specification and cell migration in the embryo. Given the diagram quantitatively determine the location (2µm or 32µm) at which the blue cells feel the steepest gradient. b. Cells use special structures called filopodia to sense their local environment. These thin projections of the actin cytoskeleton reach out and survey both the chemical and mechanical composition of the environment as the cell decides what direction to migrate in. Quantitatively determine how filopodia change the gradient sensed by the cell in the diagram below. EN 585.629 Cell and Tissue Engineering Assignment Rubric Question Component Total Point Value 1 A (1pt each) 12 B 4 2 3 3 3 4 A 4 B 4 Total Point Value = 30 References: Filopodia Image: en.wikipedia.org. ...
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