Discussion1MaladaptiveResponsestoImmuneDisorders.docx -...

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Edwards Main Post Week 2 Inflammatory Bowel Disease, Inflammatory bowel disease (IBD) is a chronic condition of the bowel that is identified by inflammation of the intestinal mucousa. The exact pathogenesis of the disease is unknown (Hammer &McPhee, 2014) ,and many theories have been proposed. IBD is has been said to be a result of an imbalance in the mucousal immune system. The imbalance causes chronic inflammation of the bowel (Bamias, G., Nyce, M. R., De La Rue, S. A., & Cominelli, F. (2005). The inflammation is not centralized to one location in the intestinal tract. The inflammatory process that is triggered by overactive lymphocytes causes the regulatory mechanism to malfunction and inhibit reoccurring inflammatory responses. While only a partial understanding of the disorder exists, there are several factors that influence the development of IBD. Physical manifestations include alternating episodees of constipation, diarrhea, bloating, and abdominal pain (Matricon , J., Barnich, N., & Ardid, D. (2010). The extra intestinal complications of IBD can include multiple organ systems. The musculoskeletal and skin are most commonly affected organs. Skin manifestations can include oral, perineal, and cutaneous areas (Brian L, H., Stephanie, e., & David Quan, S. (2012). The musculoskeletal manifestations often include arthralgias and arthritis, which commonly appear in large joints. The musculoskeletal complications are the most frequent and can precede the gastro- intestinal symptoms ( Hendrickson, B. A., Gokhale, R., & Cho, J. H. 2002). Genetic factors have been researched and found to be linked to increased susceptibility to IBD ( Zhang, Y.-Z., & Li, Y.-Y. (2014). According to the literature, there are three areas that support the hypothesis that genetics to the etiology of IBD ( Matricon, Barnich, & Ardid, 2010).
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Systemic Lupus Erythematosus Systemic Lupus Erythematosus(SLE) is an inflammatory autoimmune disease that affects multiorgans. Much like IBD the etiology of SLE is unknown ,and is characterized by alternating periods of flare up and remission.
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  • Spring '17
  • keisha lovence
  • Inflammatory bowel disease, bowel disease

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