NUR
Discussion1MaladaptiveResponsestoImmuneDisorders.docx

Discussion1MaladaptiveResponsestoImmuneDisorders.docx -...

Info icon This preview shows pages 1–3. Sign up to view the full content.

Edwards Main Post Week 2 Inflammatory Bowel Disease, Inflammatory bowel disease (IBD) is a chronic condition of the bowel that is identified by inflammation of the intestinal mucousa. The exact pathogenesis of the disease is unknown (Hammer &McPhee, 2014) ,and many theories have been proposed. IBD is has been said to be a result of an imbalance in the mucousal immune system. The imbalance causes chronic inflammation of the bowel (Bamias, G., Nyce, M. R., De La Rue, S. A., & Cominelli, F. (2005). The inflammation is not centralized to one location in the intestinal tract. The inflammatory process that is triggered by overactive lymphocytes causes the regulatory mechanism to malfunction and inhibit reoccurring inflammatory responses. While only a partial understanding of the disorder exists, there are several factors that influence the development of IBD. Physical manifestations include alternating episodees of constipation, diarrhea, bloating, and abdominal pain (Matricon , J., Barnich, N., & Ardid, D. (2010). The extra intestinal complications of IBD can include multiple organ systems. The musculoskeletal and skin are most commonly affected organs. Skin manifestations can include oral, perineal, and cutaneous areas (Brian L, H., Stephanie, e., & David Quan, S. (2012). The musculoskeletal manifestations often include arthralgias and arthritis, which commonly appear in large joints. The musculoskeletal complications are the most frequent and can precede the gastro- intestinal symptoms ( Hendrickson, B. A., Gokhale, R., & Cho, J. H. 2002). Genetic factors have been researched and found to be linked to increased susceptibility to IBD ( Zhang, Y.-Z., & Li, Y.-Y. (2014). According to the literature, there are three areas that support the hypothesis that genetics to the etiology of IBD ( Matricon, Barnich, & Ardid, 2010).
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

Systemic Lupus Erythematosus Systemic Lupus Erythematosus(SLE) is an inflammatory autoimmune disease that affects multiorgans. Much like IBD the etiology of SLE is unknown ,and is characterized by alternating periods of flare up and remission.
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.
  • Spring '17
  • keisha lovence
  • Inflammatory bowel disease, bowel disease

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern