Lec2_posted.pptx - Bio98 Lecture 2 Fermentation and...

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Bio98 Lecture 2 Fermentation and Gluconeogenesis
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Q and A for Glycolysis 1. What are the products of glycolysis? Answer: 2 pyruvate, 2 NADH, 2 ATP 2. What are the three irreversible steps of glycolysis? Answer: HK, PFK and PK 3. The product of aldolase is DHAP and ______. Give name and chemical structure. Answer: G3P.
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Learning Goals of Lecture 2 Fermentation (lactate or alcohol) The reverse: gluconeogenesis
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Cheese Anaerobic Anaerobic, yeast Wine Beer Exercise Hangover Tooth cavity NADH turns back to NAD + + lactate dehydrogenase Alcohol dehydrogenase Pyruvate decarboxylase Glucose+NAD + +ADP Glycolysis 2 pyruvate + 2 ATP + 2 NADH+H + H 3 C O COO - LDH NADH NAD + H 3 C OH COO - H Lactate Lactic acid fermentation Animal cells and lactic acid bacteria Later in the course PDC CO 2 H 3 C H O Acetaldehyde NADH NAD H 3 C OH Ethanol ADH O 2 Yeast fermentation
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Auto-Brewery Syndrome Eat sugar, make alcohol the patient appears drunk In the gut Caused by infection of yeast (e.g. antibiotic poisoning)
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Alligator: Quick burst of energy By lactic acid fermentation Generate ATP in the muscle quickly without O2 Needs long recovery to clear excess lactate (source of sourness after exercise)
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120 g/day Total 160 g/day Ready Reserve 190 g Fasting Marathon Need other source For glucose Gluconeogenesis eyes
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Gluconeogenesis Definition: synthesize glucose from 3-4 carbon precursors, normally non-carbohydrate Source of gluconeogensis Lactate: skeletal muscle, erythrocytes Amino acids: dietary protein, muscle protein breakdown Propionate: fatty acid, amino acids Glycerol, fats Starvation
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