Aldol condensation outline.docx

Aldol condensation outline.docx - Aldol condensation...

Info icon This preview shows pages 1–2. Sign up to view the full content.

Aldol condensation: synthesis of Dibenzalacetone Condensation reactions: reactions that add together two or more molecules, often with the loss of water or an alcohol. General Aldol Condensation: 2 aldehydes react in the presence of base to form a β-hydroxyaldehyde (addition product) o then lose water to form an α,β-unsaturated aldehyde OR 2 ketones react in the presence of base to form a β-hydroxyketone (addition product) o then lose water to form an α,β-unsaturated ketone A carbon-carbon bond is formed between the alpha carbon of 1 molecule and the carbonyl cation on the other addition step. Loss of water typically facilitated by heat. EXCEPT when one of the starting carbonyls has conjugation. General reaction and mechanism: This is a reaction in which the carbonyl compound acts as a nucleophile as well as an electrophile. Reaction: The addition product (the β-hydroxyaldehyde) can also be called an aldol. It contains both an aldehyde group and an alcohol group. Base catalyzed reaction – so all intermediates must be negatively charged or neutral. Requirements in order for an aldol reaction to occur In order for a carbonyl to form an enolate: It needs to have at least 1 alpha H
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern