Formulas3.pdf - #$ = This equation is followed to determine...

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3 ࠵?࠵? #$% = ࠵? ( × ࠵?࠵?࠵? This equation is followed to determine volume of plasma that is being cleared from the drug through glomerular filtration. ࠵? ( stands for unbound fraction. If ࠵?࠵?࠵? is not given, assume the value is 120mL.min -1 as an ideal value. ࠵?࠵? % = ࠵? × ࠵?࠵? #$% = ࠵? × ࠵? ( × ࠵?࠵?࠵? E F S R < 1 X X = 1 X > 1 X X ࠵?࠵? = ࠵?࠵?࠵? + ࠵?࠵?࠵? [࠵?] [࠵?࠵?] = ࠵?࠵?࠵? + ࠵?࠵?࠵? [࠵?] [1 − ࠵?] This Hendersson-Hasselbach equation applies for weak acid. When pH < pKa, most of the drug is in unionized form. When pH > pKa, most of the drug is in ionized form. As the pH of the solution increases, the degree of ionization increases. Weak acids are preferentially reabsorbed at low pH. ࠵?࠵? = ࠵?࠵?࠵? + ࠵?࠵?࠵? [࠵?࠵?]
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