Formulas2.pdf - Cl is a proportionality constant describing...

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2 Cl is a proportionality constant describing the relationship between a substance’s rate of elimination (amount per unit time) at a given time and its corresponding concentration in an appropriate fluid at that time. ࠵?࠵? #$%&’ = ࠵? × ࠵? = ࠵? × ࠵? - − ࠵? / ࠵? - ࠵?࠵? #$%&’ is the volume of plasma from which the drug is completely removed or cleared per unit of time. ࠵? - is the concentration at which drug enters the organ. ࠵? 0 is the concentration at which drug leaves the organ. (1) ࠵?࠵? 4 = ࠵? ࠵?࠵?࠵? (2) ࠵?࠵? 4 = ࠵? × ࠵? ࠵?࠵?࠵? ࠵?࠵?࠵? The knowledge of the area under the plasma concentration versus time curve is essential for the determination of the systemic, renal, and metabolic clearance of a drug. The knowledge of this parameter is also essential for the determination of the amount of the administered dose of a drug that reaches the general circulation. When a dose of a drug is administered intravenously, the entire dose is in general circulation. (1) When a drug is administered extravascularly, the entire administered dose may not
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