Lecture33-BIOL201-204-U5-TCA part 2_post-class.pdf

Lecture33-BIOL201-204-U5-TCA part 2_post-class.pdf -...

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Fun Fact: Albert Lehninger (the original textbook author) was the first to show that TCA happened in the mitochondrial matrix! To maximize our time, please start working on the reactions of the TCA as soon as you sit down. Aerobic Catabolism The Citric Acid Cycle (aka TCA, aka Kreb’s )
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TCA-1 Acceptable Enzyme Classes: 1. Synthase: The enzyme is considered a synthase (& not a hydrolase or a lyase ) as the production of citrate is the ‘most important’ reaction of the three. 2. Transferase: This reaction could also be considered as a group transfer reaction acetate part of acetyl-CoA transferred to oxaloacetate to make citrate. This is a 2-step reaction. First a condensation reaction to join the 2 reactants. Then a hydrolysis reaction to remove Coenzyme A. Purpose: to bring in 2C product of glycolysis. Enzyme mechanism: Fig 16-9
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3 What class of enzyme catalyzes TCA-2? A. Synthase B. Hydrolase C. Transferase D. Oxidoreductase E. Isomerase This is a 2-step reaction as well TCA-2 Easier to visualize of you ignore intermediate step Reaction occurs via a 2-step dehydration/ rehydration. Tricarboxylic Acid Cycle: Step 2
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TCA-3 Co-factor for boxes in step 1? A. ADP / ATP B. ATP/ ADP C. NADH / NAD + D. NAD + / NADH This is a 3-step, enzyme bound reaction Fig 16-11 Tricarboxylic Acid Cycle: Step 3
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TCA-3 This is a 3-step, enzyme bound reaction Fig 16-11 The prosthetic group required to stabilize the carbanion intermediate formed in step 2 is: A. A positively charged metal ion B. TPP Note: There is a cytosolic version of this enzyme, used for biosynthesis. In that case NADP + is used.
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