notes for abstract 5.docx - Hybrid nucleic acid...

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Hybrid nucleic acid peptide-cross-linked nanocapsules: a new drug delivery platform for simultaneous gene knockdown -Nucleic acid nanocapsule platform with nucleic acid ligands, a cross-linker, and a hydrophobic core -Asthma: chronic inflammation -Allergic reaction -Complicated biochemical pathways -Aim to target specific cells (short vs. long term treatment) -Asthma: targeting GATA-3 -Surfactant into micelle self assembly -DLS: nanoscale size analysis -Uniform in size -Cells tolerate the nucleic acid nanocapsules up to uM (concentrations determined using MTS assay for cell viability) -HeLa cells treated with NANs show colocalization
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  • Spring '14
  • Anamani,D
  • DNA, Enzyme, 60%, nucleic acid nanocapsules

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