Fatty_Acid_Oxidation_ATP_Yield_from_Fatty_Acids.pdf

Fatty_Acid_Oxidation_ATP_Yield_from_Fatty_Acids.pdf - BCH...

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1 BCH 4034 ATP Yield from Fatty Acid Oxidation A. P/O Ratios 1 NADH = 2.5 ATP 1 FADH 2 = 1.5 ATP B. ATP Yield from Acetyl-CoA (via Citric acid cycle) = 10 ATP Oxidation of acetyl-CoA produces 3 NADH (= 7.5 ATP), 1 FADH 2 (= 1.5 ATP), and 1 GTP (= 1 ATP) C. ATP Yield from Propionyl-CoA = 16.5 ATP or 17.5 ATP A. Propionyl-CoA is first converted to succinoyl-CoA with the consumption of 1 ATP (see Fig. 17-11, p. 660). Succinoyl-CoA enters the citric acid cycle and is converted to malate with the production of 1 GTP (= 1 ATP) and 1 FADH 2 (= 1.5 ATP). Malate is converted to pyruvate via the malic enzyme reaction and this reaction generates a NAD(P)H (= 2.5 ATP) (see Table 16-2, p. 633). Malate + NAD(P) + pyruvate + NAD(P)H + HCO 3 - Pyruvate is converted to acetyl-CoA via the pyruvate dehydrogenase reaction generating an NADH (= 2.5 ATP) (see Fig. 16-2, p. 616). The acetyl-CoA feeds into the TCA cycle. The net ATP yield from propionyl-CoA is: - 1 ATP from the conversion of propionyl-CoA to succinoyl-CoA 2.5 ATP from the conversion of succinoyl-CoA to malate 2.5 ATP from the conversion of malate to pyruvate 2.5 ATP from the conversion of pyruvate to acetyl-CoA 10 ATP from the oxidation of acetyl-CoA by the citric acid cycle NET ATP production from propionyl-CoA = 16.5 ATP B. Propionyl-CoA is first converted to succinoyl-CoA with the consumption of 1 ATP (see Fig. 17-11, p. 660). Succinoyl-CoA enters the citric acid cycle and is converted to oxaloacetate with the production of 1 GTP (= 1 ATP), 1 FADH 2 (= 1.5 ATP), and 1 NADH (= 2.5 ATP).
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2 Oxaloacetate is converted to pyruvate with no net ATP production by the sequential actions of PEP carboxykinase and pruvate kinase (see p. 538 and Table 16-2, p. 633). PEP carboxykinase: OAA + GTP PEP + CO 2 + GDP Pyruvate kinase: PEP + ADP → pyruvate + ATP Pyruvate is converted to acetyl-CoA via the pyruvate dehydrogenase reaction generating an NADH (= 2.5 ATP) (see Fig. 16-2, p. 616). The acetyl-CoA feeds into the TCA cycle. The net ATP yield from propionyl-CoA is: - 1 ATP from the conversion of propionyl-CoA to succinoyl-CoA 5.0 ATP from the conversion of succinoyl-CoA to oxaloacetate
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