MMSD.pdf - Mechanisms of Evolutionary Change Mutation Gene...

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Mechanisms of Evolutionary Change Mutation, Gene Flow, Selection, Genetic Drift
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Why use Hardy Weinberg Equilibrium? Null hypothesis Natural populations Understand what factors influence allele frequencies
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Really, we are interested in evolution Change in allele frequency in a population over time How do allele frequencies change? Mutation Gene flow Selection Genetic drift
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Mutation and H-W Equilibrium
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Mutation Weak mechanism of evolution Important influence in combination with selection http://phet.colorado.edu/en/simulation/natur al-selection
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Mutation of a single locus, two-allele system Let = rate of mutation from A to a Then p′ = p p and q′ = q + p If we define p = p p = p and apply some calculus (solving dp / dt = p ), then after t generations, t t e p p - = 0
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Reverse mutation Backwards mutation rate Let = rate of mutation from a to A Then q′ = q + p q
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