tut 8.pdf - Name Tutorial TA Name MBB231 Spring 2018...

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Name_______________________________________ Tutorial & TA Name___________________________ MBB231 Spring 2018 Tutorial Questions Week of March 26 th 1) Signaling pathways are structured in such a way that the cell can interpret and decode extracellular signals. Explain the four basics steps by which the signaling cascade works in the cell. Give a biological example of the “output” from a specific signaling cascade. 2) Typically, water balance in the intestines is governed by hormonal control via GPCRs, e.g., vasointestinal peptide, linked to adenylate cyclase. The cholera toxin, produced by Vibrio cholera , is a cell permeable protein that prevents hydrolysis of GTP to GDP by G a proteins. Explain the effect cholera toxin has on cell signaling, and in general terms the resulting symptoms. 3) Under resting conditions, the basal activity of phoshpodiesterase (PDE) is relatively high. Why might
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