0126_Pushalkar.docx - BC Mycology Fungal...

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BC Mycology Fungal Properties (Pushalkar) 01/26/18 have more microbial cells than the host cells help us in all metabolic processes—there are helpful and pathogenic fungi if our system is immunocompromised pathogenic microbes take over and cause disease early hx of fungi o “fungus”—“mushroom” o 1588- Giambattista della Porta o fungal spores 1 st observed o 1729- Pier Antonio Micheli o also observed spores, and showed that under proper conditions, fungal growth could be induced into same species of origin o 1761-1836- Christian Hendrik Person o est. 1 st classification of mushrooms o founder of modern mycology o 1764-1878- Elias Magnus Fries o extended the classification of fungi, using spore color, using spore color and various microscopic characteristics o techniques still used by taxonomists today o 1836- Miles Joseph Berkeley o coined word “mycology” to denote the scientific study of fungi o late 19 th -20 th C. o several mycologists modernized mycology o use of DNA sequencing technologies and phylogenetic analysis tree of life o fungal species o est. 1.5. mil (documented) o ~70,000 formally described o ~300 as human pathogens abundance and prevalence of fungi in healthy human o malassezia skin infections o aspergillas heel/foot o candida oral cavity, colon, vagina o lungs don’t normally have its own microflora but if there’s infection, you’ll see it there o some fungal species observed here too (major connection) ribosomal species o 17S in prokaryotes o 18S in eukaryotes subdivided into 60 and 40 o internally transcribed regions (ITS)—variable regions that are different in different fungi => identifiable b/w fungi regions prokaryotic vs. eukaryotic cell o prokaryote : bacteria o eukaryote : protists, fungi, animals, plants o
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BC fungal properties Eukaryotes Non-motile; larger than bacteria, ~4µm Cell wall - chitin, glucans, mannan, and complex polysaccharides Plasma membrane – ergosterol (target for the drugs); no cholesterol True nuclei, mitochondria, 80S ribosomes Heterotrophs absorptive nutrition (absorb nutrition from where they grow—cannot make their own food) Saprophytes (Decomposers), Symbionts, Parasites Unicellular or multicellular
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