Lecture 18 objectives.doc

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Lecture 18 objectives 1. Describe and define major histocompatibility complex molecules C ell surface glycoproteins -Found on cells of all higher vertebrae. -Foreign MHC found on transplanted tissues causes graft rejections. -Focus our T-lymphocytes on cells in our bodies that display foreign non-self antigens on their surfaces. (virus infected cells, macrophages, dendritic cells, B- cells that have taken up foreign, non-self antigen and are displaying it on their surface). 2. Contrast MHC I and MHC II and list the cells that carry them -MHC I: Found on all nucleated cells including the antigen presenting cells previously mentioned. -MHC II: Found on all antigen presenting cells (B- lymphocytes [produce antibodies and also phagocytize therefore they are antigen presenting cells], macrophages, dendritic cells). -Both: Bind to foreign antigen. Present virus infected cell to T- lymphocytes. 1
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3. Describe the function of MHC molecules to bind peptide fragments derived from pathogens and display them on the cell surface for recognition by the appropriate T cells. The consequences are almost always deleterious to the pathogen—virus-infected cells are killed, macrophages are activated to kill bacteria living in their intracellular vesicles, and B cells are activated to produce antibodies that eliminate or neutralize extracellular pathogens. 4. Describe in specific detail the processing of T-lymphocytes in the thymus, and explain the difference between CTL and helper T (type of CD on surface, MHC class restriction). Where do Tregs fit into this scheme? What is peripheral immune tolerance? What is DiGeorge syndrome? What causes IPEX?
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