thyroid.docx - Hypothalamic-Pituitary-Thyroid Axis 1 2 3 4...

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Hypothalamic-Pituitary-Thyroid Axis 1) Hypothalamus secretes TRH (thyrotropin-releasing hormone) 2) This stimulates anterior pituitary gland to release TSH (thyroid stimulating hormone) 3) TSH hormone to general circulation 4) TSH stimulates thyroid gland to secrete T3 and T4 a. Negative feedback – T3 and T4 inhibit TRH secretion by hypothalamus and TSh secretion by pituitary Function of Thyroid Hormone Basal Metabolism Sympathetic Nervous System Fetal and Postnatal Growth and Brain Development Thyroid hormone synthesis follicular cells – Na+/I- bring in I-, pendrin releases I- into follicular colloid Need to add more Production of Triiodothyronine (T3) and Thyroxine (T4) by the Thyroid Gland Hypothyroidism Iodine Deficiency Low thyroid hormone (T3 and T4) Negative feedback to hypothalamus leads to overproduction of TRH and TSH Abnormally high TSH – not getting enough T3/T4
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  • Spring '08
  • stein
  • thyroid gland, Thyroid-stimulating hormone, Triiodothyronine

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