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1/9/20181BiochemistryBCHE 5180/6180Evert C. Duin1“Dr. Duin, I am a pre-med student.Why do I have to know all this stuff?”2How can we use our knowledge of proteins, enzymes and metabolic pathways to benefit human kind and be good stewards of this planet?1. Taxol2. InsulinePacific yew tree (Taxus brevifolia)Practical Applications3Example 1•Taxol (paclitaxel), found in the bark of the Pacific yew tree, is a widely used anti-cancer drug•It takes 30,000 pounds of bark (2,000-4,000 trees) to produce one kilogram of taxol.•The tree has to be sacrificed to produce the bark•It can take decades for the Pacific yew to reach shoulder height, small trees yield less bark. 4
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