2018Lecture 9 (2-7-18).pdf

2018Lecture 9 (2-7-18).pdf - Chapter 13 How Cells Obtain...

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Chapter 13 How Cells Obtain Energy 1. Glycolysis 2. Fermentations 3. Breakdown of Fatty acids 4. Citric Acid Cycle 5. Central roles for Glycolysis and CAC in metabolism 6. Total energy output from one glucose molecule Figure 13-5 Glycolysis ADP+P i ! ATP Substrate-Level Phosphorylation - Partial oxidation of intermediates - Rearrangement of bonds - Enzyme-catalyzed reactions Glycolysis (splitting and partial oxidation of glucose) i) Input: 1 glucose ( 6C ) , 2 ATP, 2 ADP, 2 NAD + ii) Output: 2 pyruvate ( 2 x 3C ), 4 ATP, 2 NADH iii) Occurs in the cytoplasm Figure 13-1 Glycolysis What to do with the Pyruvate? Depends upon whether Oxygen is present or absent Figure 13-3 O 2 present (aerobic) Pyruvate enters mitochondrion Fate of Pyruvate in Presence of Oxygen (Aerobic) i) One pyruvate ( 3C ) generates 1 Acetyl CoA ( 2C ) 1 NADH 1 CO 2 ii) Occurs in Mitochondrial matrix iii) NADH regenerated to NAD + during oxidative phosphorylation Figure 13-10 i) Input: 1 pyruvate ( 3C ), 1 Coenzyme A, 1 NAD + ii) Output: 1 Acetyl( 2C )-CoA, 1 C O 2 , 1 NADH Glycolysis Pyruvate to Acetyl CoA
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