Lecture 4-Megaloblastic Anemia.pdf

Lecture 4-Megaloblastic Anemia.pdf - MegaloblasticAnemia...

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Megaloblastic Anemia Chuanyi Mark Lu, MD PhD Faculty, Department of Biology, SFSU Professor, Department of Laboratory Medicine, UCSF Hematopathologist, UCSFMC and SF VAMC
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Microcytic, hypochromic anemias (MCV<80 fL) Serum iron, Serum ferritin TIBC, and other iron studies } Decreased serum iron Iron-deficiency ACD (*usually normocytic) Normal/increased serum iron Thalassemias Hemoglobin E Sideroblastic anemia Lead poisoning Prophyrias Not All Microcytic Anemias Are Due Do Iron Deficiency
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PLASMA Protoporphyrin HEME Globins ( α 2 β 2) HEMOGLOBIN INTAKE LOSS/BLEEDING 1 5 4 3 1,2 1 1 2 1. Iron Deficiency Anemia 2. Anemia of Chronic Disease 3. Sideroblastic Anemia 4. Lead poisoning 5. Thalassemias MACROPHAGES (Spleen, Bone Marrow ) Iron Utilization ERYTHROID PRECURSORS Ferroportin Hepcidin (Liver) IL-6, TNF, ets
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