Lecture 2-RBC Structure and Function_SFSU_Lu.pdf

Lecture 2-RBC Structure and Function_SFSU_Lu.pdf -...

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Red Blood Cells Structure, Metabolism and Function Chuanyi Mark Lu, MD PhD Faculty, Department of Biology, SFSU Professor, Department of Laboratory Medicine, UCSF Hematopathologist, UCSFMC and SF VAMC
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Red Blood Cells Structure, Metabolism and Function The red blood cell membrane Hemoglobin structure and function Maintenance of red cell integrity function Metabolic pathways Red cell senescence and hemolysis
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Cell Membrane: Lipid bilayer (40%) Proteins (52%): Integral proteins: transporters (band 3), binding receptors (glycophorins), signal transducers Peripheral proteins: Cytoskeleton - spectrin, actin (band 5), ankyrin (band 2.1), band 4.1, adducin, band 4.2; GPI-anchored proteins Carbohydrate (8%): present in sialoglycoproteins (sialic acids) Cytoplasmic enzymes: Glycolytic pathway: ATP, 2,3-DPG, NADH Hexose monophosphate shunt: NADPH, reduced glutathione Carboxyl anhydrase (CA) Hemoglobins: HbA, HbA 2 , HbF Globins: α 2 β 2 , α 2 δ 2 , α 2 γ 2 Heme: protoporphyrin IX + iron (Fe 2+ ) Red Blood Cells: Overview
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The Composition and Arrangement of Red Cell Membrane Proteins
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Red Cell Membrane Cytoskeleton structure: Rely on the membrane proteins (peripheral and integral) and ATP (ATP dependent phosphorylation of spectrin) Maintain red cell shape, strength and stability Render red cell the deformability or flexibility Permeability: Freely permeable to water and anions (Cl , HCO 3
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