Lecture 3-Hematopoiesis_SFSU_Lu.pdf

Lecture 3-Hematopoiesis_SFSU_Lu.pdf - Hematopoiesis...

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Hematopoiesis Chuanyi Mark Lu, MD PhD Faculty, Department of Biology, SFSU Professor, Department of Laboratory Medicine, UCSF Hematopathologist, UCSFMC and SF VAMC Peripheral Blood Bone Marrow (Aspirate) Bone Marrow (Biopsy)
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Definition of HEMATOPOIESIS (hi ‐ˌ ma t ə‐ p ȯ i ‐ˈē‐ s ə s OR ,h ē‐ m ə‐ t ō‐ p ō i ē‐ s ə s) The formation or development of blood or of blood cells in the living body noun hematopoiesis; adjective hematopoietic
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Blood Components
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Neutrophils (granulocytes) Erythrocytes (Red blood cells) (RBC) Platelets Lymphocytes Eosinophils (granulocytes) Basophils (granulocytes) Monocytes Type of cells in normal blood White Blood Cells (WBC) : granulocytes (3 types), lymphocytes and monocytes
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Function of Blood Cells Cell Function Granulocytes (Neutrophils, Eosinophils, Basophils) & Monocytes Fight infections Lymphocytes Perform immune function (cellular and humoral immunity) Red cells (Erythrocytes) Transport oxygen (O2) and excrete carbon dioxide (CO2) Platelets Maintain hemostasis (balance between bleeding and clotting)
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All Blood Cells Come from Bone Marrow
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The Goals of this lecture To introduce and define stem cell concepts and definitions, and relate that to hematopoiesis To describe basic hematopoiesis , which provides the foundation to understand the physiology (normal) and pathophysiology (abnormal/diseased) of blood and bone marrow to be taught in this hematology course (lectures and lab sessions) cytopenia/ penia [too few] cytosis [too many] dysplasia [abnormal] leukemia [malignant/cancerous] lymphoma [malignant/cancerous] myeloma [malignant/cancerous]
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