Signal_Transduction_VideolectureNotes

Signal_Transduction_VideolectureNotes - BS 111L Fall 2007...

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BS 111L Fall 2007 Signal Transduction Video-lecture Notes I. Overview What are the three main components of a signal transduction pathway? 1. reception 2. transduction 3. response II. Signal Molecule Interacts with Receptor in the Cell Membrane (_reception_____) 1. G-protein linked receptor Outside cell is __signal binding site (receptor) ____________ Why called G-protein? _GDP ________ bound = inactive and when active is bound to__GTP ____ When a signal molecule binds to a G-protein-linked receptor, it causes a change in the __conformation ________________ of the receptor, which stimulates signal transduction. Single signal molecule can do what?_____make lots of signals and product- cAMP _________________ How to turn this off?____GTP GDP dephosphorylated _______________________________ 2. Tyrosine – kinase receptors (kinases takes _phosphate from ATP and phosphorylate some other molecule ) Different than G-protein because one ligand can activate _multiple _________ transduction pathways
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This note was uploaded on 03/21/2008 for the course BS 111L taught by Professor Alison during the Spring '08 term at Michigan State University.

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Signal_Transduction_VideolectureNotes - BS 111L Fall 2007...

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