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fa08e1bc - Metabolic Biochemistry Fall Quarter 2008 Midterm...

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Metabolic Biochemistry KEY Fall Quarter 2008 Midterm Exam 1 (270 pts.) EXAM B 1) (18 pts) The structure of the amino acid, aspartate, is shown below. For each of the following, circle each atom in , and clearly label: a. the alpha-carbon; b. the alpha- amino group; c. the R-group. 6 pts. each 2) (6 pts.) The amino acid shown in question 1 would be considered: (check one) a. Polar ____ b. Hydrophobic ____ c. Negatively charged X d. Aromatic ____ 3) (12 pts.) For the following freely reversible chemical reaction, write the net forward velocity (v) in terms of the rate constants and reactant/product concentrations. A + B C v = k 2 [A][B] – k -1 [C] (6 pts. forward rxn., 6 pts. reverse rxn.) 4) (8 pts.) A substrate binds to the active site of an enzyme, causing some of the bond angles of the substrate to be strained. Would this more likely affect the enthalpy component or the entropy component of the free energy of activation needed to reach the transition state? (You don’t need to explain why.) The enthalpy component 5) (20 pts.) How does enzymatic catalysis affect the equilibrium constant for the reaction being catalyzed? Explain. (Three sentences or less) Enzymatic catalysis has no effect on the standard free energy change (8 pts.) for the reaction. The standard free energy change determines the equilibium constant (2 pts.) , so the enzyme has no effect on the the equilibrium constant (10 pts) . C CO - O CH 2 NH 3 + H CO - O k 2 k -1 a. b. c.
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6) (20 pts.) How does enzymatic catalysis affect the rate constant (k) for the reaction being catalyzed? Explain. (Three sentences or less ) Enzymatic catalysis decreases the activation energy (8 pts.) for the reaction. A small (2 pts.) decrease in the activation energy produces a large (4 pts.) increase (6 pts.) in the rate constant .
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This note was uploaded on 01/03/2009 for the course BICD 100 taught by Professor Nehring during the Fall '08 term at UCSD.

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fa08e1bc - Metabolic Biochemistry Fall Quarter 2008 Midterm...

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