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Unformatted text preview: SN1 is based on forming the more stable carbocation Epoxides: Synthesis: treatment of an alkene with a peroxyacid (RCOOOH) such as M-CPBA (concerted) intramolecular williamson synthesis: 1.trans halohydrin formation 2.treatment with pase to deprotonate alcohol SN2 mechanism Ring Opening: Acid: SN1 or SN2 SN2 nucleophilic attack occurs at less substituted site SN1 attack occurs at more substituted site, 100% inversion due to ion pair effect Base: SN2 or E2, Grignard E2 occurs rarely, because it yields a less stable product Sheet1 Page 2 Thiols and Sulfides...
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- Fall '08
- Organic chemistry, Nucleophilic substitution, alkyl halide, intramolecular Williamson