DRUGS - Drugs influence on the Nervous System I. Common...

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Drugs influence on the Nervous System I. Common Neurotransmitters and related drugs A. Monoamines: serotonin, dopamine and norepinephrine. 1. Found throughout the cns and pns. 2. Monoamines are involved in signal transmissions for autonomic, motor, and sensory functions (in other words they are involved in most brain functions). 3. Monoamine function or influence in the brain is determined by different types of monoamine ligand-receptors in different parts of the brain. 4. Control of monoamine synapses: Neurotransmitter has short-life in synaptic cleft. DAT’s, SERT’s, MAO’s. 5. Many types of clinical depression are associated with low levels of monoamine activity in the brain. B. Enhancing monoamine function: drugs that interfere with the normal functioning of monoamine synapses. 1. SSRI’s: selective serotonin reuptake inhibitors. SSRIs bind to SERTs (serotonin transporters in the presynaptic cell’s membrane. This allows serotonin to spend more time in the synaptic cleft.
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This note was uploaded on 04/26/2009 for the course BCOR 1010 taught by Professor Latier,jef during the Fall '07 term at Colorado.

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DRUGS - Drugs influence on the Nervous System I. Common...

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