Cell Signaling

Cell Signaling - 5 How do G proteins work? Receptor...

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1 Cell Signaling What are signals? What purpose do signals serve?
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2 Signal Transduction Pathway Types of Receptors • Inhibitors can also bind, how might this have a medical application? • Cytoplasmic receptors • Plasma membrane receptors
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3 Types of Receptors • Ion Channels • Protein Kinases • G protein-linked receptors Types of plasma membrane receptors Ion Channel Receptors • Change in shape of the ion channel • Each ion channel receptor has its own signal – Chemical – Light – Sound – Change in electric charge
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4 Protein Kinase Receptors • Transfer of phosphate group to a target protein • Autophosphorylation • Protein kinase G protein-linked receptors • Group of receptors that are categorized by their arrangement in the membrane • Mobile G protein, why the G? http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/G/G-protein.gif
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Unformatted text preview: 5 How do G proteins work? Receptor Effector Activate or inhibit Example of epinephrine Biological Science 3e, Fig 8.18 c. 2008 Benjamin Cummings Example of Epinephrine Action depends on the cell type Recall Fig 15.1A 6 Cytoplasmic receptors Location Conformation Action Cellular Responses Direct transduction Indirect transduction 7 Protein Kinase Cascade RTKs Second Messengers Calcium Nitric Oxide 8 Do signals stay on forever Weve seen how many molecules activate something inside the cell Signal transduction is also highly regulated Signal Transduction Pathway 9 A little recap...
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This note was uploaded on 04/26/2009 for the course LIFESCI 2 taught by Professor Pires during the Winter '08 term at UCLA.

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Cell Signaling - 5 How do G proteins work? Receptor...

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