2-9-09 - 2/9/09 1950 to present Emphasis on molecular basis...

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2/9/09 1950 to present Molecular genetics After “Origins” Natural history becomes a science Diversity and change are testable New world view Lecture Six: Modes of Inheritance Mendelian, or simple, Traits o One gene to one trait Early studies: Archibald Garrod (1857-1936) o Pioneered the study of inborn erros of metabolism : studies of 4 inherited metabolic disorders: Albinism Pentosuria Cystinuria Alkaptonuria Metabolic disorder o Inability to metabolize tyrosine amino acid o Dark urine – mild condition o Results in severe arthritis in adulthood Garrod demonstrated that it was a genetic trait o Occurred within families o Affected children were born to normal parents
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o Autosomal recessive o Explored disorders using newly developing field of genetics o Did pedigree analysis o Brachydactyly – shortened index finger Doctoral thesis by WC Farabee, 1903 Studied 5 generations of a single family – pedigree
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2-9-09 - 2/9/09 1950 to present Emphasis on molecular basis...

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