Hypoxia Adaptations at Altitude

Hypoxia Adaptations at Altitude - Hypoxia Adaptations 1...

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Hypoxia Adaptations Hypoxia Adaptations at Altitude Jessica Burke Kansas University Biological Anthropology 304 Geetha Chitoor 13 March 2009 1
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Hypoxia Adaptations Summary “Lessons in Hypoxic Adaptation from High-Altitude Populations” by Kingman P. Strohl, published in Sleep Breath in 2008, discusses the increase of hemoglobin levels in sea-level natives in response to short-term altitude gain while this increase is not imperative for long-term elevation gain. Strohl (2008) believes genetic adaptation has occurred in high altitude populations to allow for better oxygen transportation and saturation levels. Hypoxia creates the need for humans to better efficiently transport limited amounts of oxygen to survive. Strohl (2008) observes that once a sea level native returns from adapting to high altitude, hemoglobin levels return to pre-hypoxia levels. Hemoglobin levels among high-altitude populations are relatively similar while oxygen saturation rates differ between Andean, Tibetan and Ethiopian high-altitude populations. From this observation, Strohl (2008) infers that these high-altitude populations did not follow the same processes when migrating from sea level to high altitudes; different mechanisms or combination of mechanisms are used (Stanford et al, 2009). Strohl (2008) assesses individual characteristics of high-altitude populations by calculating the variance of heritability and determines whether it is suggestive or influenced by inheritance. By using this 2
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Hypoxia Adaptations method, Strohl (2008) determines that hemoglobin concentration in high-altitude Andean and Tibetan populations are strongly inheritable. However, Tibetans show high inheritance patterns in oxygen saturation while Andeans do not. He believes this allele frequency in oxygen
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Hypoxia Adaptations at Altitude - Hypoxia Adaptations 1...

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