Mendelian Inheritance Patterns

Mendelian Inheritance Patterns - (Coffin-Lowry Syndrome,...

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Autosomal Dominant Inheritance (Achondroplasia, Huntington’s) · Affected person usually has at least one affected parent, so the trait appears in every generation regardless of its incidence (frequency) in a population. · Affects and is transmitted by both sexes. · A child of an affected x unaffected mating has a 50% chance of being affected. Autosomal Recessive Inheritance (PKU, Cystic Fibrosis) · Affected people are usually born to unaffected parents. · Parents of affected people are usually carriers. · Incidence of the disorder is affected by the level of inbreeding in the population. · Affects and is transmitted by both sexes. · Child of carrier x carrier mating has a 25% chance of being affected, and a 50% chance of being a carrier. X-Linked Dominant Inheritance
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Unformatted text preview: (Coffin-Lowry Syndrome, Incontinentia Pigmenti) · Affects either sex. · The child of an affected female has a 50% of being affected. · For an affected male, all his daughters but none of his sons are affected. X-Linked Recessive Inheritance (Color Blindness, Hemophilia, Fragile X) · Affects males almost exclusively. · Afffected males are usually born to unaffected parents; the mother is normally a carrier (heterozygote) and may have affected relatives. · Females may be affected if the father is affected and the mother is a carrier. · Sons of normal fathers x carrier mothers have a 50% chance of being affected, while daughters of normal father x carrier mothers have a 50% chance of being a carrier....
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This note was uploaded on 04/27/2009 for the course ANTHRO 304 taught by Professor Gray during the Spring '09 term at Kansas.

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