Lect. 4 Jan. 23 2008

Lect. 4 Jan. 23 2008 - Lecture 4 Lecture 4 Cell Wall of...

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Unformatted text preview: Lecture 4 Lecture 4 January 23, 2008 January 23, 2008 Cell Wall of Prokaryotes Cell Wall of Prokaryotes Cell Wall - Peptidoglycan Linear glycans crosslinked with peptides NAM NAG NAM NAG NAM NAG NAM NAG NAM NAG NAM NAG peptides peptides peptides NAM = N-acetyl muramic acid NAG = N-acetyl glucosamine Peptidoglycan Structure NAc Lactyl L-ala D-glu L-lys D-ala D-ala COOH O NAc O NAc Lactyl L-ala D-glu L-lys D-ala D-ala COOH O NAc NAc O Lactyl L-ala D-glu L-lys D-ala D-ala COOH NAc O Diamino acids Lactyl L-ala D-glu L-lys D-ala D-ala COOH O O Lactyl L-ala D-glu L-lys D-ala D-ala COOH Lactyl L-ala D-glu L-lys D-ala D-ala COOH O O O Lactyl L-ala D-glu L-lys D-ala D-ala COOH O O Lactyl L-ala D-glu L-lys D-ala D-ala COOH Lactyl L-ala D-glu L-lys D-ala D-ala COOH O O O Lactyl L-ala D-glu L-lys D-ala D-ala COOH O O Lactyl L-ala D-glu L-lys D-ala D-ala COOH Peptidoglycan Synthesis Eventually, all terminal alanines are lost Last alanine leaves Transpeptidation Diamino acids Cell walls of gram-positive and gram-negative bacteria Gram-Positive Cell • No outer membrane • Little or no periplasm Thick peptidoglycan layer Cell membrane Gram positive envelope unique properties...
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This note was uploaded on 04/27/2009 for the course BIO 340 taught by Professor Steele during the Spring '09 term at Arizona.

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Lect. 4 Jan. 23 2008 - Lecture 4 Lecture 4 Cell Wall of...

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