microRNA - transition from maternally derived mRNA to...

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RNAi amplification: In plants the siRNA can themselves serve as a primer for RNA dependent RNA polymerase (RdRP) activity produce more dsRNA that can then be cut into smaller fragments by Dicer and then interact with RISC (part three of animation)
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Another example of RNAi: MicroRNA (miRNA) Micro RNA’s encoded in genome , transcribed, modified and cut into smaller fragments by Dicer In conjunction with RISC complex, miRNA bind to 3’ untranslated regions (3’ UTR) of some transcripts and prevent translation Important mechanism of gene regulation
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miRNA and transition from egg to zygote
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Unformatted text preview: transition from maternally derived mRNA to zygote derived mRNA - change in gene expression In zygote many copies of a particular miRNA, mi370, are transcribed These miRNAs target maternal mRNA preferentially by binding to the 3 untranslated region leads to deadenylation (loss of the poly tail) and subsequent degradation of the maternal mRNA Increase in transcription of genes from zygote Normal pattern: If zygote miRNA is prevented from being processed (Dicer-free embryos) then an abnormal pattern of development occurs...
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microRNA - transition from maternally derived mRNA to...

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