Problem set 6 key

Problem set 6 key - Problem set 6 Chapter 16 1 The...

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Problem set 6 – Chapter 16 1. The following two sequences have several differences that have arisen by mutation. a) Please circle each difference and give it a # so that you can refer to it in your answer and b) indicate the type of mutation. Remember that many mutations could have more than one name. Don’t forget to use the genetic code. These are the coding strands. coyote - ATG CAT AAG CCA GAC TTA GGT AAT CCT TAT ATC --A UAC CCC wolf - ATG CAT AAA CCA GAC TTA GGT --- CCT GAT ATC GGA UAA CCC There are five mutations shown. Note that there is very little information here about the direction of the mutation, that is G to A or A to G; from the information given, either is equally likely. 1) This mutation is a base substitution, a transition at the third codon position. It is a silent mutation, because it does not result in an amino acid substitution. Another term for this mutation, mentioned in class, is synonymous (= silent). This mutation is very likely to be neutral in its effect. 2) This is a length mutation, either an addition of three bases or a deletion of three bases, thus it can be called an indel. Because it is in a multiple of three, it is not a frameshift mutation (see mutation #4). This mutation may be neutral, deleterious or lethal in its effect depending on the loss or gain of the amino acid asparginine. 3) This mutation is a base substitution, specifically a transversion and, because it causes an amino acid substitution, UAU codes for tyrosine and GAU codes for aspartic acid it is a missense mutation. Because those two amino acids are in different categories based on their R groups (non-polar aromatic and polar acidic respectively) this mutation may have a deleterious effect on the phenotype. Of course, it depends on where the amino acid is
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