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Review Ch 16 - Review Sheet for Chapter 16(section 16.1 and...

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Review Sheet for Chapter 16 (section 16.1 and parts of 16.2 and 16.3), Biology 340, Fall, 2008 1. Review the different types of mutations at the molecular level: including, but not limited to, point mutations versus length mutations (insertions or deletions (indels)), transversions, and transitions. For mutations in coding regions consider the effect of mutations on translation and the resulting polypeptide: frameshift, silent, missense, and nonsense mutations. Don’t forget to consider codon position. Review Table 16.1. Also consider terms for the effect of mutations on the phenotype such as beneficial, deleterious, lethal, and conditional mutations. 2. Many of the mutations listed above refer to mutations in the coding region of a structural gene. But consider also mutations in other regions as noted in Table 16.2. Consider also mutations in non-structural genes and their possible effect on phenotype. 3. Sickle cell anemia- review the molecular basis of the mutation that results in the sickle cell allele and the structure of the hemoglobin molecule shown in the ppt.
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