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Neurobiology of Aging exam 4

Neurobiology of Aging exam 4 - 5 How might mutations in the...

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Neurobiology of Aging Spring 2007 Exam 4 1. Based on our discussions concerning the hierarchical manner of amyloid plaque formation, for each of the figures below shade in all areas of the brain where amyloid plaques would most likely be found (6 points). 2. List 4 clinical signs of symptoms that could be used to distinguish Alzheimer’s disease from vascular dementia (4 points). 3. How could the hyperphosphorylation of tau lead to neuronal cell death? (5 points). For question 4 and 5 please refer to the figure below. Please note that this image has been converted to grayscale and inverted so that the background is white instead of black. 4. Describe the proteolytic processing of APP that would lead to the images on the left (control) and right (AD) (15 points).
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Unformatted text preview: 5. How might mutations in the APP gene lead to the image on the right? (5 points). Questions 6-8 refer to the figure below, which represents neurofibrillary tangle densities in neocortical layers in three areas of the brain. 6. What would the neurons, which are represented by the triangles in layer III of area 20, most likely look like? (2 points). 7. Name one characteristic of a neuron in layer III of area 18 that would probably never be represented as a triangle (2 points). 8. What does the pattern of NFT densities tell us about the vulnerability of hierarchical processing in Alzheimer’s Disease? (6 points). 9. Why do you think Alzheimer’s disease is so prevalent? (5 points)....
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