Exam 2003 (B) - PHA 5515 Exam Form B Total 120 points Read...

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PHA 5515 April 23, 2003 Exam Form B Total: 120 points Read each question carefully before answering. Answer only the question that is written on the page; don’t add any of your own parts to it. Remember the Academic Dishonesty Policy; keep your eyes on your own paper. Please turn in the test and answer sheets when you have finished. Good Luck!
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For the following questions use the choices below: (2 points each) A= Both statements are true: B= Both statements are false: C= The first statement is true and the second statement is false: D= The first statement is false and the second statement is true: 1. Pharmacology is defined as the basic and clinical applied science that concerns itself with how drugs are affected by the body. Toxicology deals with adverse effects to chemicals due mainly to environmental exposure. 2. Drug refers only to those chemicals approved by the FDA. Natural products are no longer used as sources for new drugs. 3. The use of Minoxidil for hair loss is an example of accidental drug design. Drugs approved by the FDA have been screened to have only beneficial effects. 4. Drugs usually have only a single mechanism of action to account for both beneficial effects and side effects. Drugs may bind to multiple receptors. 5. Understanding the mechanism of action is not a prerequisite for FDA approval of a drug. Antidepressants produce biochemical changes in a matter of days but take weeks to develop clinical effects. 6. Most drugs used today are for the treatment of disease symptoms. The total number of FDA approved drugs is limited by law to 5,000 compounds. 7. The IND (Investigational New Drug application) is filed by a company after clinical testing to get FDA approval. Phase 3 clinical trials require at least 100,000 patients to receive the new drug. 8. The Cardiac Arrhythmia Suppression Test (CAST) was a placebo controlled blind study to determine the effectiveness of drugs against ventricular fibrillation. Rezulin @ (Troglitazone) was removed from the market due to liver and heart toxicity 9. Fen-Phen (Fenfluramine and Phenteramine) was not an approved treatment for obesity. Drug treatment to reduce weight in the clinical obese is a rational use of drugs. 10. All clinical use of drugs is rational. Pharmacology is the best subject I have ever studied.
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Single answer multiple choice. Pick the one correct answer. (3 pts each) 11. Which of the following properties or conditions determine the degree of receptor occupancy by a particular drug? A. The alpha factor and intrinsic activity. B. Drug concentration and affinity. C. Receptor number and saturability. D. Ionic concentrations. E. A, B and C are true. 12. Which of the following is (are) true about log-dose-response curves? A.
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Exam 2003 (B) - PHA 5515 Exam Form B Total 120 points Read...

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