Tutorial_3_Risk_assessment.docx - Tutorial-3 Risk...

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Tutorial-3 Risk assessment 1. Suppose 30 out of 500 rats exposed to a potential carcinogen develop tumors. A control group of 300 rats not exposed to the carcinogen develops only 10 tumors. Based on these data estimate: (a) relative risk (b) the attributable risk (c) the odds ratio. Do these indicators suggest that there might be a relationship between exposure and tumor risk? 2. A 70 kg man works in an aluminum smelter for 10 years. The drinking water in the smelter contains 0.07 mg/L arsenic and 0.56 mg/L methylene chloride. His only exposure to these chemicals in water is at work with daily intake of 1L. (a) What is the hazard index (HI) associated with this exposure? (b) Does HI indicate that this is a safe level of exposure? (c) What is the incremental lifetime cancer risk for the man due solely to the water he drinks at work and does it seem to be an acceptable risk according to EPA? 3. Consider the problem of indoor air pollution caused by sidestream smoke (unfiltered smoke an idling cigarette). Suppose the sidestream smoke from one cigarette in a small
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