Muscle Physiology

Muscle Physiology - MUSCLE PHYSIOLOGY Skeletal Muscle...

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MUSCLE PHYSIOLOGY
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Skeletal Muscle Tissue Attached to bones of the skeleton Attached to eyeball Function: Generate force to produce movement (of skeleton or eyeballs) Voluntary control (generally, exception with reflexes) Require neural stimulation to contract; stimulation by somatic motor neuron
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Skeletal Muscle Fibers (cells) Multinucleated, long, cylindrically-shaped Sarcolemma T-tubules Sarcoplasm Organelles Many mitochondria Sarcoplasmic Reticulum Terminal cisterns Glycogen Myoglobin Myofibrils (proteins) Alternating light/dark pattern along length
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Figure 12-3b
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Triad Terminal cistern T-tubule Terminal cistern Electrical signals initiated on the sarcolemma, can influence the release of calcium from the SR
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Figure 12-4
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Myofibril Proteins Contractile proteins Myosin Actin Regulatory proteins Troponin Tropomyosin Others Titin Nebulin
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Sarcomere Basic unit of contraction Z-disk to Z-disk Attachment site for thin filaments A band (dark band) Length of thick filaments Some areas are thick only, some areas have overlap with thin filaments I band (light band) Thin filaments only H zone Center of A band Thick filaments only M line Center of H zone Point of attachment for thick filaments
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Figure 12-5a
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Thick Filaments 250 Myosin protein molecules Myosin 2 chains intertwined Tail region Head region: can bend at point of attachment binding site for ATP ATPAse binding site for actin (crossbridges)
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Myosin Figure 9.4 (a)(b)
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Figure 12-3e
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Thin Filaments Actin Globular molecule (G-actin) Double stranded chain of F-actin Binding sites for myosin (crossbridges) Tropomyosin Single strand along each actin strand Blocks myosin binding sites on actin Troponin Globular; 3 subunits Troponin-T: binds to tropomyosin Troponin-I: binds to actin Troponin-C: binds calcium Holds tropomyosin in place along actin strands
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Muscle Physiology - MUSCLE PHYSIOLOGY Skeletal Muscle...

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