Lecture 4 - Correlates of protection induced by vaccination

Lecture 4 - Correlates of protection induced by vaccination...

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EVO CORRELATES OF PROTECTION INDUCED BY VACCINATION Edwin Oaks, Ph.D. George Mason University Fall 2008
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EVO Immune Correlates of Protection Immunological correlates of protection : a measurable immune response in which the magnitude of the response directly correlates with protection against disease. Usually an adaptive immune response assessment B cells (antibody levels) » Secretory (mucosal) antibodies (IgA) » Serum IgG antibodies CD4+ T cells » Provide help for B cells » Provide help for CD8+ cells CD8+ T cells » CTL (kill infected cells)
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EVO Correlates of Protection From Plotkin, Clinical Infectious Diseases 2008; 47:401–9 Correlate : A specific immune response to a vaccine that is closely related to protection against infection, disease, or other defined end point Absolute correlate : A quantity of a specific immune response to a vaccine that always provides near 100% protection Relative correlate : A quantity of a specific immune response to a vaccine that usually (but not always) provides protection. Cocorrelate : A quantity of a specific immune response to a vaccine that is 1 of 2 correlates of protection and that may be synergistic with other correlates. Surrogate : A quantified specific immune response to a vaccine that is not in itself protective but that substitutes for the true (perhaps unknown) correlate
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EVO Correlation of antibody titers and protection against varicella FAMA = fluorescent antibody to membrane antigen
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EVO Immunogenicity of Various Vaccines Vaccine B cells/ antibody CD4+ T cells CD8+ T cells LICENSED VACCINES Live attenuated vaccines ( measles, mumps, rubella, oral polio virus vaccine) +++ +++ +++ Whole inactivated (hepatitis A, influenzae;
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This note was uploaded on 04/29/2009 for the course BIOL 420 taught by Professor Edwardsoaks during the Fall '08 term at George Mason.

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Lecture 4 - Correlates of protection induced by vaccination...

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