Lecture 7 - Animal Models

Lecture 7 - Animal Models - ANIMAL MODELS USED FOR VACCINE...

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EVO ANIMAL MODELS USED FOR VACCINE DEVELOPMENT Edwin Oaks, Ph.D. George Mason University Fall 2006
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EVO New Vaccine Requirements Before use in humans an investigational vaccine the following must be demonstrated: Scientific rationale Immunogenicity efficacy Data demonstrating the quality of the product Preclinical safety data
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EVO Goals of Animal Models Animal models are used to evaluate scientific rationale of vaccine products by establishing reliable approaches to investigate: Disease pathogenesis Immune response Toxicity/Safety Efficacy against challenge against target pathogen
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Edwin Oaks, Ph.D. George Mason University Fall 2006 PATHOGENSIS Ideally an animal model would replicate the disease seen in humans Target tissue (lung, GI tract, skin, brain etc) Same pathogen (agent) can be used in animal models and humans Route of inoculation Same type of immune response Th1 or Th2 Antibodies or CMI Same mechanism of action Toxin mediated? Histopathology
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This note was uploaded on 04/29/2009 for the course BIOL 420 taught by Professor Edwardsoaks during the Fall '08 term at George Mason.

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Lecture 7 - Animal Models - ANIMAL MODELS USED FOR VACCINE...

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