Lecture 10 - Meningococcal Disease

Lecture 10 - Meningococcal Disease - 18 Meningococcal...

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Unformatted text preview: 18 Meningococcal Disease Meningococcal disease is an acute, potentially severe illness caused by the bacterium Neisseria meningitidis . Illness believed to be meningococcal disease was first reported in the 16th century. The first definitive description of the disease was by Vieusseux in Switzerland in 1805. The bacterium was first identified in the spinal fluid of patients by Weichselbaum in 1887. Neisseria meningitidis is a leading cause of bacterial meningitis and sepsis in the United States. It can also cause focal disease, such as pneumonia and arthritis. N. meningitidis is also a cause of epidemics of meningitis and bacteremia in sub-Saharan Africa. The World Health Organization has estimated that meningococcal disease was the cause of 171,000 deaths worldwide in 2000. The first monovalent (group C) polysaccharide vaccine was licensed in the United States in 1974. A quadrivalent polysaccharide vaccine was licensed in 1978. Meningococcal conjugate vaccine has been licensed in United Kingdom since 1999 and has had a major impact on the incidence of type C meningococcal disease. A quadrivalent conjugate vaccine was first licensed in the United States in 2005. Neisseria meningitidis N. meningitidis , or meningococcus, is an aerobic, gram-negative diplococcus, closely related to N. gonorrhoeae , and to several nonpathogenic Neisseria species, such as N. lactamica . The organism has both an inner (cytoplasmic) and outer membrane, separated by a cell wall. The outer membrane contains several protein structures that enable the bacteria to interact with the host cells as well as perform other functions. The outer membrane is surrounded by a polysaccharide capsule that is necessary for pathogenicity because it helps the bacteria resist phagocytosis and complement-mediated lysis. The outer membrane proteins and the capsular polysaccharide make up the main surface antigens of the organism. Meningococci are classified by using serologic methods based on the structure of the polysaccharide capsule. Thirteen antigenically and chemically distinct polysaccharide capsules have been described. Some strains, often those found to cause asymptomatic nasopharyngeal carriage, are not groupable and do not have a capsule. Almost all invasive disease is caused by one of five serogroups: A, B, C, Y, and W-135. The relative importance of each serogroup depends on geographic location, as well as other factors, such as age. 269 Meningococcal Disease 18 For instance, serogroup A is a major cause of disease in sub-Saharan Africa but is rarely isolated in the United States. Meningococci are further classified on the basis of certain outer membrane proteins. Molecular subtyping using specialized laboratory techniques (e.g., pulsed-field gel elec- trophoresis) can provide useful epidemiologic information....
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Lecture 10 - Meningococcal Disease - 18 Meningococcal...

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