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Ch18-Cancer08 - Chapters 12 18 Cancer Cancer Set of...

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Chapters 12 & 18 Cancer
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Cancer Set of diseases Cells altered Growth control mechanisms are bypassed
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Types of Genes Associated with Cancer Genes for regulation of cell growth and division: Growth factors Growth factor receptors Intracellular signalling molecules
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Gene Alterations in Cancer Spontaneous changes (mutations) Environmentally-induced mutations Chemical carcinogens X-rays Certain viruses
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Viruses and Cancer Linked since 1911 Rous sarcoma virus - cancers in chickens Others: Epstein-Barr virus -> Burkitt’s lymphoma Human papiloma virus -> Cervical cancer HTLV-1 -> Leukemia (adult) HHV8 -> Kaposi’s
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Cancer “Genes” Two types Oncogenes Stimulate cell growth and division Tumor suppressor genes Prevent cell growth and division
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Oncogenes Mutated versions of proto-oncogenes Mutations can result in: expression of oncoprotein at the wrong time excessive expression of the oncoprotein hyperactive oncoproteins
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Fig 18.20 Mutations of Proto-oncogenes
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