DietHealth.09 - Nutrition Concept No. 5 Humans have...

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Nutrition Concept No. 5 Humans have adaptive mechanisms for managing fluctuations in nutrient intake.
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Homeostasis The processes whereby the body maintains the levels of nutrients in cells and tissues within narrow ranges
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NO HOMEOSTASIS TOXIC HOMEOSTASIS FAILS HOMEOSTASIS DEFICIENT Deficient Toxic Concentration of Nutrient Within Organism Level of Nutrient Intake Concept of Homeostasis
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Mechanisms for Homeostasis Increase or decrease nutrient absorption in the intestine Increase or decrease nutrient excretion Shunt excesses to body stores Draw down body stores Reduce metabolic rate to conserve energy
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Mechanisms for Homeostasis Increase or decrease absorption in the intestine
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Iron homeostasis Intestinal absorption is up- regulated in iron deficiency Intestinal absorption is down-regulated in iron adequacy 0 5 10 15 20 25 Fe Deficiency Fe Adequacy Fe Absorption (%)
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DMT-1 DcytB Fe 3+ Fe 2+ Fe 2+ Fe 2+ Ferritin Ferroportin Fe 2+ Ferroportin Intestinal Lumen Blood Transferrin Fe 3+ Fe 3+ Hephaestin Enterocyte Brush Border Membrane Basolateral membrane Hepcidin Fe deficiency
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Nutrient Stores For some nutrients, excesses may be deposited in specialized compartments as tissue stores
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Nutrients That Can Be Stored Iron (liver and bone marrow) Vitamin A (liver) Vitamin B 12 (liver) Energy (as fat and glycogen) Fat: subcutaneous, viceral Glycogen: liver and muscle
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Nutrients that cannot be stored in substantial amounts Water soluble vitamins (e.g. vitamin C) Electrolytes (e.g. sodium and potassium) Protein
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Relationships Between Diet and Health We eat to live What we eat and how much we eat matters a lot
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DietHealth.09 - Nutrition Concept No. 5 Humans have...

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