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Unformatted text preview: MCB 102 Professor Melis 3/20/09 Lecture 25 ASUC Lecture Notes Online is the only authorized note-taking service at UC Berkeley. Do not share, copy or illegally distribute (electronically or otherwise) these notes. Our student-run program depends on your individual subscription for its continued existence. These notes are copyrighted by the University of California and are for your personal use only. D O N O T C O P Y Sharing or copying these notes is illegal and could end note taking for this course. ANNOUNCEMENTS Okay, I think were ready to begin. Professor Buchanan could not come to class today, and he asked me to give this lecture. Im Professor Melis from the Plant and Microbial Bio department. Im currently teaching Plant Biochemistry and Evolution and Stress Physiology and Molecular Biology as undergraduate classes, and Biochemistry of Biofuels as a graduate class. My lab actually works in the field of biofuels and to change the synthesis of plants in order to generate biofuels instead of sugars. I usually dont teach MCB 102, but I do sometimes give one or two guest lectures every year. LECTURE Today, were going to address something thats fairly relevant, and thats mitochondria. Mitochondria are one of the few bioenergetic organelles in the cells. Lecture XI: Oxidative phosphorylation and photophosphorylation I: oxidative phosphorylation Well be talking about activities of mitochondria, NAD-linked enzymes, electron carriers, mitochondrial complexes, the chemiosmotic hypothesis, transport of reducing equivalents, and regulatory aspects. MCB 102 ASUC Lecture Notes Online: Approved by the UC Board of Regents 3/20/09 D O N O T C O P Y Sharing or copying these notes is illegal and could end note taking for this course. 2 We begin with the first slide, an overview of the catabolism of proteins, fats, and carbohydrates in the three stages of cellular respiration. This shows how the mitochondria play a role in burning metabolites, forming carbon dioxide and water. The first stage is acetyl CoA formation . Amino acids, fatty acids, and glucose are the most common forms that are broken down. Acetyl CoA, an intermediate, serves as a very important molecule. Once generated, in the mitochondria, there is a second stage of acetyl CoA oxidation . There are many intermediates, including oxaloacetate and citrate. In the end, the acetyl CoA is oxidized to produce two carbon dioxides and four electrons that are carried by NADH and FADH 2 . These reduced electron carriers give their electrons to the electron transport chain, which is stage three, electron transfer and oxidative phosphorylation . This leads to the generation of ATP. Where do mitochondria come from?...
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This note was uploaded on 05/07/2009 for the course MCB 58168 taught by Professor Thorner during the Spring '09 term at University of California, Berkeley.
- Spring '09