LEC 10 - MCB 102 Professor Buchanan 3/18/09 Lecture 24 ASUC...

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MCB 102 Professor Buchanan 3/18/09 Lecture 24 ASUC Lecture Notes Online is the only authorized note-taking service at UC Berkeley. Do not share, copy or illegally distribute (electronically or otherwise) these notes. Our student-run program depends on your individual subscription for its continued existence. These notes are copyrighted by the University of California and are for your personal use only. D O N O T C O P Y Sharing or copying these notes is illegal and could end note taking for this course. ANNOUNCEMENTS Good morning. I want to announce again that my office hours this Thursday and Friday are canceled this week. Another professor will be giving the lecture for oxidative phosphorylation. LECTURE Last time, we talked about figure 18-3, showing the human digestive tract. I suggest you look it over and read it. Lecture X: Integration and hormonal regulation of mammalian metabolism I think the reading assignment in lecture 23 is a very good review for everything we’ve covered up to now. Today, we’ll be talking about tissue- specific metabolism and hormonal regulation of fuel metabolism. It’s a rather broad coverage, but most of you have probably already heard. There are many specialized functions of mammalian tissues. The small intestine absorbs nutrients. The portal vein carries nutrients. The liver meets the needs of the many metabolic needs of tissues, processing fats, carbohydrates, proteins, and lipids. The pancreas secretes insulin and glucagon in response to blood glucose levels. The brain transports ions to
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MCB 102 ASUC Lecture Notes Online: Approved by the UC Board of Regents 3/18/09 D O N O T C O P Y Sharing or copying these notes is illegal and could end note taking for this course. 2 maintain membrane potentials and sends signals to other organs. The lymphatic system carries lipids from intestine to liver. We will now review the main metabolic pathways for glucose 6-phosphate in the liver. We saw that glucose 6-phosphate can be turned into pyruvate and into acetyl CoA, which then goes into the citric acid cycle. Acetyl CoA can also be used to synthesize fatty acids. Also, we talked about the pentose phosphate pathway to create nucleotides. There are five main pathways that you should be well familiar with. Figure 23-14 shows the metabolism of amino acids in the liver. Starting with amino acids, we can obtain nucleotides or tissue proteins. In addition, it can yield pyruvate, which can be broken down into acetyl CoA. The acetyl CoA can be used to generate fatty acids or go into the citric acid cycle as well. The glucose-alanine cycle is common in
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This note was uploaded on 05/07/2009 for the course MCB 58168 taught by Professor Thorner during the Spring '09 term at University of California, Berkeley.

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LEC 10 - MCB 102 Professor Buchanan 3/18/09 Lecture 24 ASUC...

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